Heroin UK ,Outcome of overdose heroin


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Heroin is an illegal substance , highly addictive drug processed from morphine, a
natural substance extracted from the seed pod of certain varieties
of poppy plants. Heroin is typically sold as a Brown or white powder that is
“cut” with sugars, starch, quinine, or powdered milk . Pure heroin is a white powder
with a bitter taste that predominantly originates in South America and, to a lesser
extent, from Southeast Asia, and dominates U.S. markets east of the Mississippi
River. Highly pure heroin can be snorted or smoked and may be more appealing to
new users because it eliminates the stigma associated with injection drug use. “Black
tar” heroin is sticky like roofing tar or hard like coal and is predominantly produced
in Mexico and sold in U.S. areas west of the Mississippi River.3
The dark colour associated with black tar heroin results from crude processing methods that leave
behind impurities. Impure heroin is usually dissolved, diluted, and injected into veins,
muscles, or under the skin.

Outcome or side effects of overdose heroin intake

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To begin , Heroin binds to and activates specific
receptors in the brain called mu-opioid
receptors (MORs). All human bodies contains
naturally occurring chemicals called
neurotransmitters that binds to these
receptors throughout the brain and body to
regulate pain(ease), hormone release, and feelings
of well-being.
When MORs are activated
in the reward centre of the brain, they
stimulate the release of the neurotransmitter
dopamine, causing a sensation of pleasure.
The consequences or outcome of activating opioid ,
receptors with externally administered
opioids ,such as heroin (versus naturally
occurring chemicals within our bodies)
depend on a variety of factors: how much
is used, where in the brain or body it binds,
how strongly it binds and for how long,
how quickly it gets there, and what happens

Moreso , Once heroin enters the brain, it is converted to morphine and binds rapidly to opioid
receptors.Heroin Abusers typically report feeling a surge of pleasurable sensation—a
“rush.” The intensity of the rush is a function of how much drug is taken and how
rapidly the drug enters the brain and binds to the opioid receptors. With heroin,
the rush is usually accompanied by a warm flushing of the skin, dry mouth, and a
heavy feeling in the extremities, which may be accompanied by nausea, vomiting,
and severe itching. After the initial effects, users usually will be drowsy for several
hours; mental function is clouded; heart function slows; and breathing is also
severely slowed, sometimes enough to be life-threatening. Slowed breathing can
also lead to coma and permanent brain damage.

Furthermore , Heroin also have some long term effect of use ,Long term heroin use ,may cause changes in the physical structure, and physiology of the brain, creating long-term imbalances in neuronal and hormonal systems that are not easily
reversed. Researchers have shown some deterioration of the brain’s white matter due to heroin use, which may affect decision-making abilities, the ability to regulate behaviour, and responses to stressful situations. Heroin also produces profound degrees of tolerance and physical dependence. Tolerance occurs when more and
more of the drug is required to achieve the same effects. With physical dependence, the body adapts to the presence of the drug and withdrawal symptoms occur if use is reduced abruptly. Withdrawal may occur within a few hours after the last time the drug is taken. Symptoms of withdrawal include restlessness, muscle and bone
pain, insomnia, diarrhoea, vomiting, cold flashes with goose bumps (“cold turkey”),
and leg movements. Major withdrawal symptoms peak between 24–48 hours after
the last dose of heroin and subside after about a week. However, some people have
shown persistent withdrawal signs for many months. Finally, repeated heroin use
often results in addiction—a chronic relapsing disease that goes beyond physical
dependence and is characterized by uncontrollable drug-seeking no matter the
consequences. Heroin is extremely addictive no matter how it is administered,
although routes of administration that allow it to reach the brain the fastest
(i.e., injection and smoking) increase the risk of addiction. Once a person
becomes addicted to heroin, seeking and using the drug becomes their primary
purpose in life.

Solution to heroin overdose consumption

Heroin UK , 1kg heroin online , wholesale heroin , heroin for sale uk

To start with , Overdose is a dangerous and deadly
consequence of heroin use. A large
dose of heroin depresses heart rate and
breathing to such an extent that a user
cannot survive without medical help.
Naloxone (e.g., Narcan®) is an opioid
receptor antagonist medication that can
eliminate all signs of opioid intoxication
to reverse an opioid overdose. It works
by rapidly binding to opioid receptors,
preventing heroin from activating
Because of the huge increase
in overdose deaths from prescription
opioid abuse, there has been greater
demand for opioid overdose prevention
services. Naloxone that can be used
by nonmedical personnel has been
shown to be cost-effective and save
lives. In April 2014, the U.S. Food and
Drug Administration (FDA) approved
a naloxone hand-held auto-injector
called Ezio, which rapidly delivers a
single dose of naloxone into the muscle
or under the skin, buying time until
medical assistance can arrive. Since
Ezio can be used by family members
or caregivers, it greatly expands access
to naloxone.
NIDA and the FDA
are working with drug manufacturers
to support the development of nasal
spray formulations of this live-saving

In addition, the Substance
Abuse and Mental Health Services
Administration (SAMHSA) released
an Opioid Overdose Prevention Toolkit
in August 2013 that provides helpful
information necessary to develop
policies and practices to prevent opioid ,related overdoses and deaths. The
kit provides material tailored for first
responders, treatment providers, and
individuals recovering from an opioid

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